@Former-Member, that is such a great question.
I am quite sure that for my son, the answer is yes. He has always felt the negatives in life so much strongly than the positives. I remember when he was about 5 years old, telling me that he wanted to die... a statement that broke my heart but I came to realise that it was because when any negative thing happened in his life, it was just immensely shattering to him. The positives were, in comparison, just momentary flashes.
I don't think that for a person who is like him, that life is destined to be entirely full of pain. He's 21 years old now and pursuing his dreams and succeeding (albeit with significantly more stress than others in his situation). Life is immensely more challenging for him that it has ever been for me. But he is aware of his weaknesses as well as his strengths, and he makes strategic decisions that enable him to compete with those who do not have his tendencies.
Parenting him has also really made me aware of the hidden disabilities that we all have... and I'm indebted to him for that.
Thanks for such an great question 